It is designed for those who access, use, and rely upon, accounting information, but do not have accounting training or background. Those who attend this GLOMACS Accounting for Non-Accountants training seminar will gain a clear understanding of the structures of the accounting system, the information it contains, and how it can be accessed. You will learn, from numerous practical examples and illustrations, how the information on business transactions and activities, input to the accounting system is used throughout the organization.
Mitogens substances outside the cell which stimulate cell proliferation and growth factors usually act on cell surface receptors to activate signalling molecules which affect gene transcription leading to accelerated cell growth. Oncogene proteins are also present in the intracellular signalling from integrins surface proteins mediating cell motility, attachment and associated growth signals.
Whereas tumor suppressor gene mutations can be described as "faulty brakes", oncogenes can be characterized as "stuck accelerator pedal". Most growth factors act by binding to transmembrane tyrosine kinase receptors on the cell surface membrane.
From the point of view of cancer, the most notable cell signalling pathway is the one activated by the Ras protein attached to the inner cell surface associated with the tyrosine kinase receptor. Oncogenes of the Ras protein mutated proto-oncogenes cause Ras to be perpetually active, whether a growth factor is present or at the tyrosine kinase receptor or not.
Nearly a third of all human cancers have the ras oncogene, forming a defective Ras protein. Both the p53 tumor-suppressor gene and the ras oncogene promote VEGF secretion — promoting angiogenesis growth of new blood vessels required to support new, rapidly-growing cancer tissue.
Cell Receptor Signalling to the Nuclear Transcription Factors The transcription factor proteins Fos, Jun and Myc come from proto-oncogenes designated as immediate early genes because they are expressed rapidly after mitogen stimulation and have a short half-life.
The proteins from immediate early genes are transcription factors produced in response to cell stimuli, and these transcription factors cause the production of functional proteins. Oncogenes produced mutated forms of the immediate early genes which can increase the activity of the proteins they form.
Overexpression of the Myc growth factor can lead to the angiogenesis and tumor-cell invasiveness that characterizes malignancy. Myc overexpression increases Bcl2 protein and decreases p53 protein, both effects being anti-apoptotic and pro-proliferative.
Myc DNA targets are often tumor-suppressor genes that are frequently silenced by methylation in cancer. The ability of G-protein-coupled signaling pathways to undergo desensitization to receptor substances "tolerance" is part of the basis for addiction to opiates, caffeine, benzodiazepines and nicotine.
Thus, PTEN mutations which make the protein defective release two pathways which can lead to excess proliferation and thus to cancer.
Neutrophils and macrophages immune system cells enter the wound and fight bacteria by creating toxic free radicals like hydrogen peroxide, peroxynitrite and the hydroxyl radical.
Antioxidant enzymes like selenium-containing glutathione peroxidase and thioredoxin reductase protect neutrophils, macrophages and other tissues from the free radicals intended to destroy pathogens.
Macrophages release growth factors to promote tissue re-growth. Continuous exposure to the free radical peroxynitrite leads to DNA mutation. Growth factors from macrophages promote proliferation of new cancer cells.
Non-infectious causes of chronic inflammation such as tobacco smoke and asbestos also contribute significantly to cancer.
Although the main carcinogenic effects of inflammation are on tumor promotion and progression, chronic inflammation can also lead to tumor initiation. Septic shock is the main cause of multiple organ system failure, the leading cause of mortality in intensive care units.
The hyperproliferation associated with chronic inflammation leads not only to decreased genome stability and increased mutation, but to hypermethylation see Section F. There are also great differences in susceptibility to cancer between different organs and tissues, not all of which can be attributed to environmental differences.
Cancer results from DNA changes that re-direct cellular activity away from anything other than reproduction, growth and invasion of other tissues.
Although cancer is a disease of DNA mutation, the vast majority of those mutations are acquired due to environmental influences especially chemical rather than by heredity.
It is, however, possible to inherit a predisposition to cancer which, nonetheless, requires additional environmental influences to become manifest.
Were the gene not recessive, the embryo would quickly be consumed by cancer. Being recessive means that an additional mutation is required for the genes to become manifest. But by already having one of the two mutations required for activity, the homozygous mutant conditions necessary for malfunctioning tumor suppressor protein becomes much more likely to occur.
The oncogenic DNA viruses consist of four main groups: Although adenoviruses can cause tumors in rodents, there is no evidence that they do so in humans.
The Human PapillomaVirus HPV associated with cervical carcinoma is a papovirus that produces two oncoproteins, one of which binds to p53 protein and the other of which disrupts the action of the RB gene. Insofar as both p53 and pRb are both tumor suppressor proteins that can stop the cell cycle, blocking the action of both proteins is a major step leading to cellular "immortalization" through telomerase usuallyor ALT Alternative Lengthening of Telomeres.
Hepadnaviruses infect the liver and thereby cause a large portion of the cancers seen in underdeveloped countries. Herpes simplex virus probably contributes urogenital and oropharangeal cancers. In developed countries the Epstein-Barr herpesvirus is associated with mononucleosis, a non-malignant form of lymphocyte proliferation.
And in southern China Epstein-Barr is responsible for many cases of nasopharyngeal carcinoma. Although retroviruses and other RNA viruses contribute to cancer in animals, they rarely do so in humans except through indirect effects.
The HIV retrovirus is associated with cancer in AIDS patients, but most often this effect is due to reduced immune system action against herpesviruses. Epigenetic Dysregulation Epigenetic refers to modifications of gene expression that occur without changes in DNA sequence.
Many such changes may be heritable. The primary mechanisms of epigenetics are histone acetylation causing gene expressionhistone deacetylation causing gene silencinghistone methylation and DNA methylation both usually causing gene silencing.Endodontic therapy, also known as endodontic treatment or root canal therapy, is a treatment sequence for the infected pulp of a tooth which results in the elimination of infection and the protection of the decontaminated tooth from future microbial invasion.
Root canals, and their associated pulp chamber, are the physical hollows within a tooth that are naturally inhabited by nerve tissue. On completion of this course you will be able to: Describe the principles of root cause analysis ; Explain the objectives of root cause analysis as a procedure to find and evaluate the causes of problems.
Accounting is not a root cause of the financial crisis, but it has an important role to play in its resolution In today’s economy one of the roles of accountants is to provide sound and accurate advice to users and are supposed to have an objective view to a business.
While many colleges offer Forensic Accounting degree programs at the graduate level, Franklin University is one of the few schools offering an accredited online Forensic Accounting bachelor's degree in this high-demand field. Gain a solid foundation in accounting. Root cause analysis is the process of looking for the reasons why a problem is occurring.
By correcting the underlying root causes of problems, the incidence of . The meeting is an important regular event for the company.
Business units and major subsidiaries report their monthly results and other matters during these meetings.